By Adam Graham-Silverman, CQ Staff

The Senate confirmed Hillary Rodham Clinton on Wednesday as the 67th secretary of State by an overwhelming vote of 94-2.

Clinton, D-N.Y., resigned her Senate seat shortly after the vote.

John Cornyn , R-Texas, who had blocked a voice vote on Clinton’s nomination Tuesday, was among those who voted “yes.” Republicans Jim DeMint of South Carolina and David Vitter of Louisiana were the only “no” votes. John McCain , R-Ariz., asked Republicans to dispense with the roll call and confirm Clinton by voice vote, but DeMint insisted.

Making his first comments on the Senate floor in the 111th Congress, McCain said the election he had lost to President Obama showed a need to act quickly to address crises. “I think the message that the American people are sending us now is they want us to work together and get to work,” he said.

Cornyn said he had concluded after conversations with Clinton that she was well-qualified for the job, but he remained concerned about potential conflicts of interest related to how former President Bill Clinton’s foundation discloses its donors.

Cornyn pointed to Obama’s calls for a more transparent government and endorsed stricter disclosure requirements and a ban on foreign donors to the foundation.

“We should not let our respect for Sen. Clinton or our admiration for the many good works of the Clinton Foundation blind us to the danger of perceived conflicts of interest caused by the solicitation of hundreds of millions of dollars from foreign and some domestic sources,” Cornyn said.

As an example, he cited an Indian politician who donated at least $1 million to the foundation while Congress was considering a civilian nuclear deal (PL 110-369) with India.

Cornyn said Clinton told him she would be open to implementing new disclosure requirements for all charitable foundations, not just her husband’s.

When Obama announced his choice of Clinton in December, the presidential transition team revealed a complex agreement with the foundation that requires annual disclosure and some limits on soliciting foreign contributions.

That was sufficient for Foreign Relations Chairman John Kerry , D-Mass., who praised the Clinton Foundation’s anti-poverty work and said the Clintons do not stand to benefit personally from it.

“I’m confident that sufficient checks and balances exist here and that we should proceed forward,” Kerry said. “We need to remember that the world is moving at a fast pace. . . . Gaza is waiting. The Middle East is waiting.”

The Foreign Relations Committee approved Clinton’s nomination Jan. 15, 16-1. Vitter was the only “no” vote.